PPP2CA protein (Homo sapiens) - STRING interaction network

PPP2CA protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	PPP2CA	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but no [...] (309 aa)
		(Homo sapiens)
Predicted Functional Partners:
	PPP2R1A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; The PR65 subunit of p [...] (589 aa)		•	•	•	0.999
	PPP2R2A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform; The B regulatory subu [...] (447 aa)		•	•	•	0.999
	PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma isoform; The B regulatory subunit might mod [...] (524 aa)		•	•	•	0.999
	PPP2R1B	protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; The PR65 subunit of pr [...] (667 aa)		•		•	0.999
	PPP2R4	protein phosphatase 2A activator, regulatory subunit 4; Reversibly stimulates the variable phos [...] (323 aa)		•	•	•	0.999
	SGOL1	shugoshin-like 1 (S. pombe); Plays a central role in chromosome cohesion during mitosis by prev [...] (561 aa)		•	•	•	0.999
	STRN	striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffold [...] (780 aa)		•	•		0.999
	PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform; The B regulatory subunit might m [...] (467 aa)	•	•	•	•	0.999
	PPP2R2C	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform; The B regulatory subu [...] (447 aa)		•	•	•	0.999
	PPP2R5D	protein phosphatase 2, regulatory subunit B', delta isoform; The B regulatory subunit might mod [...] (602 aa)		•	•	•	0.999

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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