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  CCL4L1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CCL4L1
chemokine (C-C motif) ligand 4-like 1; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B (92 aa)
(Homo sapiens)
Predicted Functional Partners:
CCR5
chemokine (C-C motif) receptor 5; Receptor for a number of inflammatory CC-chemokines including [...] (352 aa)
      0.968
CCR1
chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- [...] (355 aa)
      0.891
CCR3
chemokine (C-C motif) receptor 3; Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin- [...] (355 aa)
      0.888
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13; Cytokine that binds to TNFRSF13B/TACI an [...] (250 aa)
       0.869
CX3CR1
chemokine (C-X3-C motif) receptor 1; Receptor for the CX3C chemokine fractalkine and mediates b [...] (355 aa)
      0.859
CXCR1
chemokine (C-X-C motif) receptor 1; Receptor to interleukin-8, which is a powerful neutrophils [...] (350 aa)
      0.857
CXCR4
chemokine (C-X-C motif) receptor 4; Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a [...] (356 aa)
      0.836
CXCR3
chemokine (C-X-C motif) receptor 3; Receptor for CXCL9, CXCL10 and CXCL11 and mediates the prol [...] (415 aa)
       0.800
CCR9
chemokine (C-C motif) receptor 9; Receptor for chemokine SCYA25/TECK. Subsequently transduces a [...] (369 aa)
       0.800
CCR6
chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC [...] (374 aa)
       0.800
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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