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  PHF21A protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PHF21A
PHD finger protein 21A; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits AOF2/LSD1-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (680 aa)
(Homo sapiens)
Predicted Functional Partners:
KDM1A
lysine (K)-specific demethylase 1A; Histone demethylase that demethylates 'Lys-4' of histone H3 [...] (852 aa)
      0.998
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
     0.995
HMG20B
high-mobility group 20B; Required for correct progression through G2 phase of the cell cycle an [...] (317 aa)
      0.986
RCOR1
REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represse [...] (482 aa)
      0.981
HDAC2
histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (582 aa)
      0.976
HDAC9
histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (1069 aa)
      0.974
HDAC3
histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (428 aa)
      0.939
NCOR1
nuclear receptor co-repressor 1; Mediates transcriptional repression by certain nuclear recepto [...] (2440 aa)
      0.938
MTA2
metastasis associated 1 family, member 2; May be involved in the regulation of gene expression [...] (668 aa)
      0.933
HDAC5
histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (1123 aa)
      0.920
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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