PHF21A protein (Homo sapiens) - STRING interaction network

PHF21A protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PHF21A	PHD finger protein 21A; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits AOF2/LSD1-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (680 aa)
		(Homo sapiens)
Predicted Functional Partners:
	KDM1A	lysine (K)-specific demethylase 1A; Histone demethylase that demethylates 'Lys-4' of histone H3 [...] (852 aa)	•		•	0.998
	HDAC1	histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)	•	•	•	0.995
	HMG20B	high-mobility group 20B; Required for correct progression through G2 phase of the cell cycle an [...] (317 aa)	•		•	0.986
	RCOR1	REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represse [...] (482 aa)	•		•	0.981
	HDAC2	histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (582 aa)	•		•	0.976
	HDAC9	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (1069 aa)		•	•	0.974
	HDAC3	histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (428 aa)		•	•	0.939
	NCOR1	nuclear receptor co-repressor 1; Mediates transcriptional repression by certain nuclear recepto [...] (2440 aa)		•	•	0.938
	MTA2	metastasis associated 1 family, member 2; May be involved in the regulation of gene expression [...] (668 aa)		•	•	0.933
	HDAC5	histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (1123 aa)		•	•	0.920

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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