ENSG00000232810 protein (Homo sapiens) - STRING interaction network

ENSG00000232810 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	ENSG00000232810	Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)(TNF-a)(Cachectin) [Contains Tumor necrosis factor, membrane form;Tumor necrosis factor, soluble form]; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (233 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)	•	•	0.986
	IFNG	interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamm [...] (166 aa)	•	•	0.984
	ICAM1	intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein [...] (532 aa)		•	0.963
	IL1B	interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)		•	0.954
	CD40	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG (277 aa)		•	0.954
	TRAF2	TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)	•	•	0.948
	TFPT	TCF3 (E2A) fusion partner (in childhood Leukemia) (253 aa)		•	0.944
	ADAM17	ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its matur [...] (824 aa)	•	•	0.898
	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/T [...] (461 aa)	•	•	0.875
	FANCA	Fanconi anemia, complementation group A; DNA repair protein that may operate in a postreplicati [...] (1455 aa)		•	0.867

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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