MECP2 protein (Homo sapiens) - STRING interaction network

MECP2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	MECP2	methyl CpG binding protein 2 (Rett syndrome); Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (498 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SIN3A	SIN3 homolog A, transcription regulator (yeast); Acts as a transcriptional repressor. Interacts [...] (1273 aa)	•	•	0.999
	CDKL5	cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 (1030 aa)	•	•	0.997
	DNMT1	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemim [...] (1632 aa)	•	•	0.995
	HDAC1	histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)	•	•	0.993
	ATRX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); Could be [...] (2492 aa)	•	•	0.987
	DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta; Required for genome wide de novo methylation and is [...] (853 aa)		•	0.985
	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member [...] (1590 aa)	•	•	0.975
	DLX5	distal-less homeobox 5 (289 aa)		•	0.974
	BDNF	brain-derived neurotrophic factor; During development, promotes the survival and differentiatio [...] (329 aa)		•	0.964
	UBE3A	ubiquitin protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ub [...] (875 aa)		•	0.961

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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