SCN10A protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
sodium channel, voltage-gated, type X, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity) (1956 aa)
(Homo sapiens)
Predicted Functional Partners:
nerve growth factor (beta polypeptide); Nerve growth factor is important for the development an [...] (241 aa)
sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates [...] (688 aa)
calmodulin 1 (phosphorylase kinase, delta); Calmodulin mediates the control of a large number o [...] (149 aa)
solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical ro [...] (348 aa)
leptin; May function as part of a signaling pathway that acts to regulate the size of the body [...] (167 aa)
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; [...] (409 aa)
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve gro [...] (796 aa)
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and deg [...] (770 aa)
neuron navigator 1; May be involved in neuronal migration (By similarity) (1874 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (3%)