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  SCN10A protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SCN10A
sodium channel, voltage-gated, type X, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity) (1956 aa)
(Homo sapiens)
Predicted Functional Partners:
NGF
nerve growth factor (beta polypeptide); Nerve growth factor is important for the development an [...] (241 aa)
       0.939
SCLT1
sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates [...] (688 aa)
      0.833
CALM1
calmodulin 1 (phosphorylase kinase, delta); Calmodulin mediates the control of a large number o [...] (149 aa)
       0.800
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical ro [...] (348 aa)
       0.784
LEP
leptin; May function as part of a signaling pathway that acts to regulate the size of the body [...] (167 aa)
       0.780
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; [...] (409 aa)
       0.780
REN
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
       0.774
NTRK1
neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve gro [...] (796 aa)
       0.766
APP
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and deg [...] (770 aa)
       0.748
NAV1
neuron navigator 1; May be involved in neuronal migration (By similarity) (1874 aa)
       0.744
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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