EWSR1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
Ewing sarcoma breakpoint region 1; Might normally function as a repressor. EWS-fusion- proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (656 aa)
(Homo sapiens)
Predicted Functional Partners:
BRCA1 associated RING domain 1; The BRCA1-BARD1 heterodimer coordinates a diverse range of cell [...] (777 aa)
Wilms tumor 1; Transcription factor that plays an important role in cellular development and ce [...] (517 aa)
POU class 4 homeobox 1; Probable transcription factor which may play a role in the regulation o [...] (419 aa)
activating transcription factor 1; This protein binds the cAMP response element (CRE) (consensu [...] (271 aa)
splicing factor 1; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to [...] (639 aa)
nuclear receptor subfamily 4, group A, member 3; Binds to the B1A response-element (637 aa)
Friend leukemia virus integration 1; Sequence-specific transcriptional activator. Recognizes th [...] (452 aa)
PTK2B protein tyrosine kinase 2 beta; Involved in calcium induced regulation of ion channel and [...] (1009 aa)
protein arginine methyltransferase 2; Probably methylates the guanidino nitrogens of arginyl re [...] (433 aa)
Bruton agammaglobulinemia tyrosine kinase; Plays a crucial role in B-cell ontogeny. Transiently [...] (659 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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additional (white) nodes

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