CXCL1 protein (Homo sapiens) - STRING interaction network

CXCL1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity (107 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CXCR2	chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil c [...] (360 aa)		•	•	•		0.999
	CXCR1	chemokine (C-X-C motif) receptor 1; Receptor to interleukin-8, which is a powerful neutrophils [...] (350 aa)		•	•	•		0.996
	CXCL2	chemokine (C-X-C motif) ligand 2; Produced by activated monocytes and neutrophils and expressed [...] (107 aa)	•		•	•	•	0.989
	CXCL3	chemokine (C-X-C motif) ligand 3; Ligand for CXCR2 (By similarity). Has chemotactic activity fo [...] (107 aa)	•		•	•	•	0.986
	CCL5	chemokine (C-C motif) ligand 5; Chemoattractant for blood monocytes, memory T-helper cells and [...] (91 aa)			•	•		0.984
	CCL20	chemokine (C-C motif) ligand 20; Chemotactic factor that attracts lymphocytes and, slightly, ne [...] (96 aa)	•		•	•		0.984
	CCR1	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- [...] (355 aa)			•	•		0.971
	CXCL11	chemokine (C-X-C motif) ligand 11; Chemotactic for interleukin-activated T-cells but not unstim [...] (94 aa)			•	•		0.969
	CCR5	chemokine (C-C motif) receptor 5; Receptor for a number of inflammatory CC-chemokines including [...] (352 aa)			•	•		0.968
	IL1B	interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)	•			•		0.966

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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