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  ZP3 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ZP3
zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation (424 aa)
(Homo sapiens)
Predicted Functional Partners:
FIGLA
folliculogenesis specific basic helix-loop-helix; Germline specific transcription factor implic [...] (219 aa)
       0.952
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5'-stem-loop of U4 s [...] (128 aa)
       0.940
FURIN
furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous en [...] (794 aa)
      0.916
ACR
acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of try [...] (421 aa)
      0.855
GDF9
growth differentiation factor 9; Required for ovarian folliculogenesis (By similarity) (454 aa)
       0.776
MSH6
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). H [...] (1360 aa)
       0.772
PLAC1
placenta-specific 1; May play a role in placental development (212 aa)
       0.766
AR
androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that re [...] (920 aa)
       0.726
SPAG9
sperm associated antigen 9; The JNK-interacting protein (JIP) group of scaffold proteins select [...] (1321 aa)
       0.712
H1FOO
H1 histone family, member O, oocyte-specific; May play a key role in the control of gene expres [...] (346 aa)
       0.710
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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