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  KL protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
KL
klotho; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) (1012 aa)
(Homo sapiens)
Predicted Functional Partners:
FGF23
fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phospha [...] (251 aa)
       0.992
FGF1
fibroblast growth factor 1 (acidic); The heparin-binding growth factors are angiogenic agents i [...] (155 aa)
       0.972
FGF21
fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the ind [...] (209 aa)
       0.945
TRPV5
transient receptor potential cation channel, subfamily V, member 5; Constitutively active calci [...] (729 aa)
       0.918
FGFR1
fibroblast growth factor receptor 1; Receptor for basic fibroblast growth factor. Receptor for [...] (822 aa)
      0.892
PTH
parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing [...] (115 aa)
       0.891
FGFR4
fibroblast growth factor receptor 4; Receptor for acidic fibroblast growth factor. Does not bin [...] (802 aa)
      0.883
FGF19
fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down [...] (216 aa)
       0.872
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase); Receptor for VEGF or VEGFC [...] (1356 aa)
       0.849
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; This is the receptor for stem ce [...] (976 aa)
       0.843
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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