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  TFAP2A protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis [...] (437 aa)
(Homo sapiens)
Predicted Functional Partners:
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; Interferes w [...] (270 aa)
      0.994
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in re [...] (785 aa)
       0.986
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; Acts as tran [...] (184 aa)
      0.979
CASP6
caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases [...] (293 aa)
     0.979
CREB1
cAMP responsive element binding protein 1; This protein binds the cAMP response element (CRE), [...] (341 aa)
       0.961
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene [...] (1255 aa)
       0.961
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
       0.954
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta; Important transcriptional activator in the regula [...] (345 aa)
       0.951
EPS15
epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May [...] (896 aa)
       0.950
CDH1
cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion prot [...] (882 aa)
       0.946
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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