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  PAX6 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PAX6
paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes (436 aa)
(Homo sapiens)
Predicted Functional Partners:
SIX3
SIX homeobox 3; May be involved in visual system development (332 aa)
      0.994
MITF
microphthalmia-associated transcription factor; Transcription factor for tyrosinase and tyrosin [...] (520 aa)
      0.990
SOX2
SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with O [...] (317 aa)
      0.986
NEUROG2
neurogenin 2; Involved in neurogenesis (By similarity) (272 aa)
       0.982
SOX3
SRY (sex determining region Y)-box 3 (446 aa)
      0.979
IPO13
importin 13; Functions in nuclear protein import as nuclear transport receptor. Serves as recep [...] (963 aa)
      0.974
PKNOX1
PBX/knotted 1 homeobox 1 (436 aa)
      0.967
TRIM11
tripartite motif-containing 11; May have E3 ubiquitin ligase activity. May contribute to the re [...] (468 aa)
      0.963
SHH
sonic hedgehog homolog (Drosophila); Binds to the patched (PTC) receptor, which functions in as [...] (462 aa)
       0.963
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
       0.962
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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