version_number_image
  CYBB protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CYBB
cytochrome b-245, beta polypeptide; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc (570 aa)
(Homo sapiens)
Predicted Functional Partners:
CYBA
cytochrome b-245, alpha polypeptide; Critical component of the membrane-bound oxidase of phagoc [...] (195 aa)
     0.999
NCF1
neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (nece [...] (390 aa)
     0.999
NCF2
neutrophil cytosolic factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required fo [...] (526 aa)
    0.999
NCF1C
neutrophil cytosolic factor 1C pseudogene; NCF2, NCF1, and a membrane bound cytochrome b558 are [...] (390 aa)
      0.998
NCF4
neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme s [...] (348 aa)
     0.997
RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma [...] (211 aa)
     0.992
NOXO1
NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX [...] (376 aa)
      0.991
NOXA1
NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide- producing NADPH oxi [...] (483 aa)
      0.991
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates [...] (335 aa)
       0.961
MT-CYB
mitochondrially encoded cytochrome b; Component of the ubiquinol-cytochrome c reductase complex [...] (380 aa)
       0.960
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (2%)
Permalink