TNFRSF1B protein (Homo sapiens) - STRING interaction network

TNFRSF1B protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity (461 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TRAF2	TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)		•	•	•		0.999
	TRAF1	TNF receptor-associated factor 1; Adapter protein and signal transducer that links members of t [...] (416 aa)		•	•	•		0.995
	TNF	tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)		•		•		0.992
	ADAM17	ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its matur [...] (824 aa)			•	•		0.984
	BIRC2	baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with [...] (618 aa)			•	•		0.974
	TRADD	TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically ass [...] (312 aa)			•	•		0.974
	BIRC3	baculoviral IAP repeat-containing 3; Apoptotic suppressor. The BIR motifs region interacts with [...] (604 aa)			•	•		0.958
	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)			•	•	•	0.939
	RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF si [...] (671 aa)			•	•		0.927
	IL6	interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is [...] (212 aa)	•			•		0.916

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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