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  CLCN5 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CLCN5
chloride channel 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (816 aa)
(Homo sapiens)
Predicted Functional Partners:
OCRL
oculocerebrorenal syndrome of Lowe; Converts phosphatidylinositol 4,5-bisphosphate to phosphati [...] (901 aa)
       0.960
WWP2
WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase which accepts u [...] (870 aa)
      0.892
LRP2
low density lipoprotein-related protein 2; Acts together with cubilin to mediate HDL endocytosi [...] (4655 aa)
       0.892
KIF3B
kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chro [...] (747 aa)
       0.889
CUBN
cubilin (intrinsic factor-cobalamin receptor); Cotransporter which plays a role in lipoprotein, [...] (3623 aa)
       0.886
PTH
parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing [...] (115 aa)
       0.879
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa; Hydrolyzes the calcium-mobilizing second messenger [...] (913 aa)
       0.816
RAB5A
RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endoso [...] (215 aa)
       0.814
CLC
Charcot-Leyden crystal protein; May have both lysophospholipase and carbohydrate-binding activi [...] (142 aa)
       0.786
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member [...] (1480 aa)
       0.785
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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