PINK1 protein (Homo sapiens) - STRING interaction network

PINK1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	PINK1	PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (581 aa)
		(Homo sapiens)
Predicted Functional Partners:
	PARK7	Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androge [...] (189 aa)		•	0.993
	SNCA	synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)		•	0.992
	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)	•	•	0.986
	ATP13A2	ATPase type 13A2 (1180 aa)		•	0.970
	HTRA2	HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific [...] (458 aa)		•	0.964
	CDC37	microRNA 1181; Co-chaperone that binds to numerous kinases and promotes their interaction with [...] (378 aa)		•	0.943
	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase [...] (223 aa)		•	0.907
	MAPT	microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be i [...] (776 aa)		•	0.906
	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)		•	0.896
	MT-ND6	NADH-ubiquinone oxidoreductase chain 6 (EC 1.6.5.3)(NADH dehydrogenase subunit 6); Core subunit [...] (174 aa)		•	0.887

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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