TGFBR1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
transforming growth factor, beta receptor 1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta (503 aa)
(Homo sapiens)
Predicted Functional Partners:
SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 r [...] (426 aa)
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
FK506 binding protein 1A, 12kDa; May play a role in modulation of ryanodine receptor isoform-1 [...] (108 aa)
transforming growth factor, beta 3; Involved in embryogenesis and cell differentiation (412 aa)
transforming growth factor, beta receptor II (70/80kDa); On ligand binding, forms a receptor co [...] (592 aa)
endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding o [...] (658 aa)
SMAD family member 3; Transcriptional modulator activated by TGF-beta (transforming growth fact [...] (425 aa)
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)
transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 depende [...] (442 aa)
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Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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