TGFBR1 protein (Homo sapiens) - STRING interaction network

TGFBR1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	TGFBR1	transforming growth factor, beta receptor 1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta (503 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SMAD7	SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 r [...] (426 aa)	•	•	•		0.999
	TGFB1	transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)	•	•	•		0.999
	SMAD2	SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)	•	•	•		0.999
	FKBP1A	FK506 binding protein 1A, 12kDa; May play a role in modulation of ryanodine receptor isoform-1 [...] (108 aa)	•		•		0.999
	TGFB3	transforming growth factor, beta 3; Involved in embryogenesis and cell differentiation (412 aa)	•	•	•		0.999
	TGFBR2	transforming growth factor, beta receptor II (70/80kDa); On ligand binding, forms a receptor co [...] (592 aa)	•	•	•	•	0.999
	ENG	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding o [...] (658 aa)	•	•	•		0.999
	SMAD3	SMAD family member 3; Transcriptional modulator activated by TGF-beta (transforming growth fact [...] (425 aa)	•	•	•		0.998
	SMAD4	SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)	•	•	•		0.998
	TGFB2	transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 depende [...] (442 aa)	•	•	•		0.997

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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