POLE3 protein (Homo sapiens) - STRING interaction network

POLE3 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit); Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (147 aa)
		(Homo sapiens)
Predicted Functional Partners:
	POLE	polymerase (DNA directed), epsilon; Participates in DNA repair and in chromosomal DNA replicati [...] (2286 aa)	•	•	•	•		0.999
	POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit); May play a role in allowing polymerase epsi [...] (117 aa)	•	•	•	•		0.997
	CHRAC1	chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 an [...] (131 aa)	•	•		•		0.991
	YEATS2	YEATS domain containing 2; Component of the ATAC complex, a complex with histone acetyltransfer [...] (1422 aa)			•	•		0.978
	MBIP	MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of [...] (344 aa)			•	•		0.976
	POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit); Participates in DNA repair and in chromosom [...] (527 aa)		•	•	•		0.976
	BAZ1A	bromodomain adjacent to zinc finger domain, 1A; May play a role in transcriptional regulation. [...] (1556 aa)		•		•		0.974
	DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2); The association of the DR [...] (176 aa)	•	•	•	•	•	0.969
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member [...] (1052 aa)		•		•		0.969
	CCDC101	coiled-coil domain containing 101; Involved in transcriptional regulation, probably through ass [...] (293 aa)		•	•	•		0.959

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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