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  MBL2 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MBL2
mannose-binding lectin (protein C) 2, soluble (opsonic defect); Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA (248 aa)
(Homo sapiens)
Predicted Functional Partners:
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); Fu [...] (728 aa)
     0.999
MASP2
mannan-binding lectin serine peptidase 2; Serum protease that plays an important role in the ac [...] (686 aa)
     0.998
CALR
calreticulin; Molecular calcium binding chaperone promoting folding, oligomeric assembly and qu [...] (417 aa)
      0.983
IGHV4-39
immunoglobulin heavy variable 4-39 (125 aa)
       0.934
CD93
CD93 molecule; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lect [...] (652 aa)
      0.932
CD79A
CD79a molecule, immunoglobulin-associated alpha; Required in cooperation with CD79B for initiat [...] (226 aa)
       0.926
C1R
complement component 1, r subcomponent; C1r B chain is a serine protease that combines with C1q [...] (719 aa)
       0.894
C1S
complement component 1, s subcomponent; C1s B chain is a serine protease that combines with C1q [...] (688 aa)
       0.891
PTX3
pentraxin-related gene, rapidly induced by IL-1 beta; Plays a role in the regulation of innate [...] (381 aa)
       0.887
PRSS1
protease, serine, 2 (trypsin 2); Has activity against the synthetic substrates Boc-Phe- Ser-Arg [...] (247 aa)
       0.880
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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