MBL2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

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mannose-binding lectin (protein C) 2, soluble (opsonic defect); Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA (248 aa)
(Homo sapiens)
Predicted Functional Partners:
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); Fu [...] (728 aa)
mannan-binding lectin serine peptidase 2; Serum protease that plays an important role in the ac [...] (686 aa)
calreticulin; Molecular calcium binding chaperone promoting folding, oligomeric assembly and qu [...] (417 aa)
immunoglobulin heavy variable 4-39 (125 aa)
CD93 molecule; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lect [...] (652 aa)
CD79a molecule, immunoglobulin-associated alpha; Required in cooperation with CD79B for initiat [...] (226 aa)
complement component 1, r subcomponent; C1r B chain is a serine protease that combines with C1q [...] (719 aa)
complement component 1, s subcomponent; C1s B chain is a serine protease that combines with C1q [...] (688 aa)
pentraxin-related gene, rapidly induced by IL-1 beta; Plays a role in the regulation of innate [...] (381 aa)
protease, serine, 2 (trypsin 2); Has activity against the synthetic substrates Boc-Phe- Ser-Arg [...] (247 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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