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  MPL protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MPL
myeloproliferative leukemia virus oncogene; Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses (635 aa)
(Homo sapiens)
Predicted Functional Partners:
THPO
thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakar [...] (353 aa)
     0.999
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
     0.997
SOCS1
suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feed [...] (211 aa)
     0.986
NUDC
nuclear distribution gene C homolog (A. nidulans); Plays a role in neurogenesis and neuronal mi [...] (331 aa)
       0.965
TPO
thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to y [...] (933 aa)
      0.963
GATA1
GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probabl [...] (413 aa)
       0.953
TYK2
tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in [...] (1187 aa)
      0.950
SH2B3
SH2B adaptor protein 3; Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB [...] (575 aa)
       0.949
EPO
erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocy [...] (193 aa)
       0.945
JAK1
Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma [...] (1154 aa)
      0.921
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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