PTEN protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

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phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
(Homo sapiens)
Predicted Functional Partners:
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase implicated in signaling pa [...] (1052 aa)
membrane associated guanylate kinase, WW and PDZ domain containing 2; Seems to act as scaffold [...] (1455 aa)
phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and Pt [...] (1068 aa)
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylatin [...] (480 aa)
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Scaffold protein tha [...] (358 aa)
mechanistic target of rapamycin (serine/threonine kinase); Kinase subunit of both mTORC1 and mT [...] (2549 aa)
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; Scaffold protein tha [...] (337 aa)
phosphoinositide-3-kinase, catalytic, gamma polypeptide; 3-phosphorylates the cellular phosphoi [...] (1102 aa)
membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding pro [...] (1481 aa)
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Active Prediction Methods:
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Co-expression Experiments Databases Textmining
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