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  HPSE2 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
HPSE2
heparanase 2; Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies (592 aa)
(Homo sapiens)
Predicted Functional Partners:
IDS
iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan s [...] (550 aa)
       0.899
KRT8
keratin 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the co [...] (483 aa)
       0.805
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alph [...] (1039 aa)
       0.784
THOC1
THO complex 1; Component of the THO subcomplex of the TREX complex. The TREX complex specifical [...] (657 aa)
       0.784
HPR
haptoglobin-related protein; Haptoglobin combines with free plasma hemoglobin, preventing loss [...] (348 aa)
       0.740
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a rece [...] (1181 aa)
       0.734
VWF
von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of plat [...] (2813 aa)
       0.692
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a recep [...] (788 aa)
       0.661
GP1BB
glycoprotein Ib (platelet), beta polypeptide; Gp-Ib, a surface membrane protein of platelets, p [...] (206 aa)
       0.641
CNTN3
contactin 3 (plasmacytoma associated); Contactins mediate cell surface interactions during nerv [...] (1028 aa)
       0.615
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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