PARK2 protein (Homo sapiens) - STRING interaction network

PARK2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May pr [...] (465 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SNCAIP	synuclein, alpha interacting protein (919 aa)	•	•	•		0.999
	SNCA	synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)	•	•	•		0.999
	UBC	ubiquitin C (685 aa)	•		•	•	0.997
	SEPT5	septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis [...] (369 aa)	•		•		0.994
	PINK1	PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stre [...] (581 aa)	•		•		0.986
	PARK7	Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androge [...] (189 aa)	•		•		0.986
	GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a un [...] (613 aa)	•		•		0.985
	AIMP2	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly [...] (320 aa)	•		•		0.985
	UBE2L3	ubiquitin-conjugating enzyme E2L 3; Catalyzes the covalent attachment of ubiquitin to other pro [...] (154 aa)	•		•		0.984
	MAPT	microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be i [...] (776 aa)	•		•		0.981

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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