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  EGLN1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
EGLN1
egl nine homolog 1 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (426 aa)
(Homo sapiens)
Predicted Functional Partners:
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functi [...] (826 aa)
     0.999
EPAS1
endothelial PAS domain protein 1; Transcription factor involved in the induction of oxygen regu [...] (870 aa)
     0.998
ARNT
aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) recept [...] (789 aa)
      0.981
ING4
inhibitor of growth family, member 4; Component of the HBO1 complex which has a histone H4- spe [...] (249 aa)
      0.980
OS9
osteosarcoma amplified 9, endoplasmic reticulum lectin; Lectin which functions in endoplasmic r [...] (667 aa)
     0.979
EPO
erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocy [...] (193 aa)
       0.942
VHL
von Hippel-Lindau tumor suppressor; Involved in the ubiquitination and subsequent proteasomal d [...] (213 aa)
      0.930
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyze [...] (1970 aa)
      0.929
SIAH2
seven in absentia homolog 2 (Drosophila); E3 ubiquitin-protein ligase that mediates ubiquitinat [...] (324 aa)
       0.923
EGLN2
egl nine homolog 2 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (407 aa)
     0.907
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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