MAPK8 protein (Homo sapiens) - STRING interaction network

MAPK8 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	MAPK8	mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) (427 aa)
		(Homo sapiens)
Predicted Functional Partners:
	JUN	jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)	•	•	•		0.999
	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) gro [...] (711 aa)	•	•	•		0.999
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)	•	•	•		0.999
	ATF2	activating transcription factor 2; Transcriptional activator, probably constitutive, which bind [...] (505 aa)	•		•		0.999
	IRS1	insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)	•	•	•		0.999
	MAP2K4	mitogen-activated protein kinase kinase 4; Dual specificity kinase that activates the JUN kinas [...] (399 aa)	•	•	•	•	0.999
	DUSP10	dual specificity phosphatase 10; Involved in the inactivation of MAP kinases. Has a specificity [...] (482 aa)	•	•	•		0.999
	MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3; The JNK-interacting protein (JIP) gro [...] (1336 aa)	•	•	•		0.998
	DUSP1	dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase E [...] (367 aa)	•	•	•		0.998
	JUND	jun D proto-oncogene; Binds an AP-1 site and upon cotransfection stimulates the activity of a p [...] (347 aa)	•	•	•		0.998

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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