version_number_image
  DNMT1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
DNMT1
DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] (1632 aa)
(Homo sapiens)
Predicted Functional Partners:
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
    0.999
PCNA
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
     0.999
UHRF1
ubiquitin-like with PHD and ring finger domains 1; Putative E3 ubiquitin-protein ligase. May pa [...] (805 aa)
     0.997
RB1
retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Ac [...] (928 aa)
     0.996
MECP2
methyl CpG binding protein 2 (Rett syndrome); Chromosomal protein that binds to methylated DNA. [...] (498 aa)
      0.995
DMAP1
DNA methyltransferase 1 associated protein 1; Involved in transcription repression and activati [...] (467 aa)
      0.994
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta; Required for genome wide de novo methylation and is [...] (853 aa)
      0.994
CBX5
chromobox homolog 5 (HP1 alpha homolog, Drosophila); Component of heterochromatin. Recognizes a [...] (191 aa)
      0.993
MBD4
methyl-CpG binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair [...] (580 aa)
       0.992
SETD7
SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically [...] (366 aa)
      0.989
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (9%)
Permalink