NUDT3 protein (Homo sapiens) - STRING interaction network

NUDT3 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Als [...] (172 aa)
		(Homo sapiens)
Predicted Functional Partners:
	DMPK	dystrophia myotonica-protein kinase; Critical to the modulation of cardiac contractility and to [...] (639 aa)		•	0.675
	ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa)		•	0.619
	SOX30	SRY (sex determining region Y)-box 30; Transcriptional activator. Binds to the DNA sequence 5'- [...] (753 aa)	•		0.607
	AIRE	autoimmune regulator; Transcriptional regulator that binds to DNA as a dimer or as a tetramer, [...] (545 aa)		•	0.593
	NUDT5	nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities [...] (219 aa)		•	0.571
	MGAM	maltase-glucoamylase (alpha-glucosidase); May serve as an alternate pathway for starch digestio [...] (1857 aa)		•	0.518
	HMGN4	high mobility group nucleosomal binding domain 4 (90 aa)		•	0.516
	GOLGA6B	golgi autoantigen, golgin subfamily a, 6A (693 aa)		•	0.499
	TSC22D3	TSC22 domain family, member 3; Protects T-cells from IL2 deprivation-induced apoptosis through [...] (200 aa)		•	0.474
	NDP	Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and L [...] (133 aa)		•	0.432

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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