EPHA2 protein (Homo sapiens) - STRING interaction network

EPHA2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	EPHA2	EPH receptor A2; Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (976 aa)
		(Homo sapiens)
Predicted Functional Partners:
	EFNA1	ephrin-A1; Plays an important role in angiogenesis and tumor neovascularization. The recruiteme [...] (205 aa)	•	•	•	0.999
	EFNA5	ephrin-A5; May function actively to stimulate axon fasciculation. Induces compartmentalized sig [...] (228 aa)	•	•	•	0.999
	EFNA3	ephrin-A3 (238 aa)	•	•	•	0.999
	EFNA4	ephrin-A4; May play a role in the interaction between activated B lymphocytes and dendritic cel [...] (207 aa)	•	•	•	0.997
	EFNA2	ephrin-A2 (213 aa)	•	•	•	0.997
	CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence; Participates in signal transducti [...] (906 aa)	•	•	•	0.982
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)		•	•	0.981
	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)	•	•	•	0.970
	TIAM1	T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and conn [...] (1591 aa)	•	•	•	0.968
	GRB2	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)	•	•	•	0.968

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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