NR3C2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
nuclear receptor subfamily 3, group C, member 2; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (984 aa)
(Homo sapiens)
Predicted Functional Partners:
sodium channel, nonvoltage-gated 1, gamma; Sodium permeable non-voltage-sensitive ion channel i [...] (649 aa)
cortistatin; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to cen [...] (155 aa)
serum/glucocorticoid regulated kinase 1; Protein kinase that plays an important role in cellula [...] (526 aa)
B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-depen [...] (239 aa)
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
sodium channel, nonvoltage-gated 1, beta; Sodium permeable non-voltage-sensitive ion channel in [...] (640 aa)
nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) which is implicated in v [...] (1203 aa)
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)
tripartite motif-containing 24; Interacts selectively in vitro with the AF2-activating domain o [...] (1050 aa)
natriuretic peptide precursor A; A potent vasoactive substance which is thought to play a key r [...] (151 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (5%)