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  NR3C2 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NR3C2
nuclear receptor subfamily 3, group C, member 2; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (984 aa)
(Homo sapiens)
Predicted Functional Partners:
SCNN1G
sodium channel, nonvoltage-gated 1, gamma; Sodium permeable non-voltage-sensitive ion channel i [...] (649 aa)
       0.958
CORT
cortistatin; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to cen [...] (155 aa)
       0.954
SGK1
serum/glucocorticoid regulated kinase 1; Protein kinase that plays an important role in cellula [...] (526 aa)
       0.953
BCL2
B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-depen [...] (239 aa)
       0.952
REN
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
       0.949
SCNN1B
sodium channel, nonvoltage-gated 1, beta; Sodium permeable non-voltage-sensitive ion channel in [...] (640 aa)
       0.926
NOS3
nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) which is implicated in v [...] (1203 aa)
       0.895
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)
      0.887
TRIM24
tripartite motif-containing 24; Interacts selectively in vitro with the AF2-activating domain o [...] (1050 aa)
      0.875
NPPA
natriuretic peptide precursor A; A potent vasoactive substance which is thought to play a key r [...] (151 aa)
       0.856
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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