BRCA1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage [...] (1863 aa)
(Homo sapiens)
Predicted Functional Partners:
retinoblastoma binding protein 8; May modulate the functions ascribed to BRCA1 in transcription [...] (897 aa)
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
ubiquitin interaction motif containing 1; Ubiquitin-binding protein that specifically recognize [...] (719 aa)
breast cancer 2, early onset; Involved in double-strand break repair and/or homologous recombin [...] (3418 aa)
estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)
BRCA1 interacting protein C-terminal helicase 1; DNA-dependent ATPase and 5' to 3' DNA helicase [...] (1249 aa)
BRCA1 associated RING domain 1; The BRCA1-BARD1 heterodimer coordinates a diverse range of cell [...] (777 aa)
Fanconi anemia, complementation group D2; Required for maintenance of chromosomal stability. Pr [...] (1471 aa)
H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset o [...] (143 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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