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  IRAK4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IRAK4
interleukin-1 receptor-associated kinase 4; Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1 (460 aa)
(Homo sapiens)
Predicted Functional Partners:
MYD88
myeloid differentiation primary response gene (88); Adapter protein involved in the Toll-like r [...] (309 aa)
     0.999
PELI1
pellino homolog 1 (Drosophila); Scaffold protein involved in the IL-1 signaling pathway via its [...] (418 aa)
     0.999
TRAF6
TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)
     0.998
IL1R1
interleukin 1 receptor, type I; Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and int [...] (569 aa)
      0.996
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      0.992
IRAK2
interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 en [...] (625 aa)
    0.991
TICAM2
TMED7-TICAM2 readthrough; Functions in LPS-TLR4 signaling to regulate the MYD88- independent pa [...] (235 aa)
     0.985
IRAK1
interleukin-1 receptor-associated kinase 1; Binds to the IL-1 type I receptor following IL-1 en [...] (712 aa)
    0.980
PELI3
pellino homolog 3 (Drosophila); Scaffold protein which probably links Toll-like receptors (TLRs [...] (469 aa)
      0.977
PELI2
pellino homolog 2 (Drosophila); Scaffold protein which probably links Toll-like receptors (TLRs [...] (420 aa)
      0.977
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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