version_number_image
  SMAD4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SMAD4
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor (552 aa)
(Homo sapiens)
Predicted Functional Partners:
SKI
v-ski sarcoma viral oncogene homolog (avian); May play a role in terminal differentiation of sk [...] (728 aa)
     0.999
SMAD2
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
   0.999
SMAD3
SMAD family member 3; Transcriptional modulator activated by TGF-beta (transforming growth fact [...] (425 aa)
    0.999
SMAD1
SMAD family member 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) [...] (465 aa)
    0.999
FOXH1
forkhead box H1; Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT] [...] (365 aa)
     0.998
SKIL
SKI-like oncogene; May have regulatory role in cell division or differentiation in response to [...] (684 aa)
     0.998
TGFBR1
transforming growth factor, beta receptor 1; On ligand binding, forms a receptor complex consis [...] (503 aa)
     0.998
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in re [...] (785 aa)
     0.997
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
     0.997
TGFBR2
transforming growth factor, beta receptor II (70/80kDa); On ligand binding, forms a receptor co [...] (592 aa)
     0.996
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (14%)
Permalink