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  PTPN11 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (593 aa)
(Homo sapiens)
Predicted Functional Partners:
GAB2
GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane re [...] (676 aa)
     0.999
GAB1
GRB2-associated binding protein 1; Probably involved in EGF and insulin receptor signaling (724 aa)
     0.999
PDGFRB
platelet-derived growth factor receptor, beta polypeptide; Receptor that binds specifically to [...] (1106 aa)
     0.999
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
    0.999
FRS2
fibroblast growth factor receptor substrate 2; Adapter protein that links FGR and NGF receptors [...] (508 aa)
     0.999
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
     0.999
IRS1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)
     0.999
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. Th [...] (918 aa)
     0.999
EGFR
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
     0.999
INSR
insulin receptor; This receptor binds insulin and has a tyrosine-protein kinase activity. Isofo [...] (1382 aa)
     0.999
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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