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  TRPC6 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TRPC6
transient receptor potential cation channel, subfamily C, member 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion (931 aa)
(Homo sapiens)
Predicted Functional Partners:
NPHS2
nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomeru [...] (383 aa)
      0.988
ORAI1
ORAI calcium release-activated calcium modulator 1; Ca(2+) release-activated Ca(2+) (CRAC) chan [...] (303 aa)
      0.986
PRODH2
proline dehydrogenase (oxidase) 2; Seems to play a role in the development or function of the k [...] (1241 aa)
      0.986
TRPC3
transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor- [...] (921 aa)
    0.981
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
      0.967
TRPC5
transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor- [...] (973 aa)
    0.958
TRPC1
transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor- [...] (759 aa)
    0.957
TRPC4
transient receptor potential cation channel, subfamily C, member 4; Thought to form a receptor- [...] (982 aa)
    0.957
KIRREL
kin of IRRE like (Drosophila); Plays a significant role in the normal development and function [...] (757 aa)
      0.956
RNF24
ring finger protein 24; May play a role in TRPCs intracellular trafficking (169 aa)
       0.950
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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