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  SMPD1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity (631 aa)
(Homo sapiens)
Predicted Functional Partners:
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into [...] (411 aa)
     0.990
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Converts sphing [...] (423 aa)
      0.981
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II); Catalyzes th [...] (655 aa)
      0.969
FADD
Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)
      0.964
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
      0.964
UGCG
UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphing [...] (394 aa)
      0.962
CERK
ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phos [...] (537 aa)
      0.960
GALC
galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsph [...] (685 aa)
      0.958
ACER2
alkaline ceramidase 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty aci [...] (275 aa)
      0.955
ACER1
alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty aci [...] (264 aa)
      0.955
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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