SMPD1 protein (Homo sapiens) - STRING interaction network

SMPD1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity (631 aa)
		(Homo sapiens)
Predicted Functional Partners:
	ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into [...] (411 aa)	•	•	•	0.990
	SMPD2	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Converts sphing [...] (423 aa)		•	•	0.981
	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II); Catalyzes th [...] (655 aa)		•	•	0.969
	FADD	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)		•	•	0.964
	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)		•	•	0.964
	UGCG	UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphing [...] (394 aa)		•	•	0.962
	CERK	ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phos [...] (537 aa)		•	•	0.960
	GALC	galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsph [...] (685 aa)		•	•	0.958
	ACER2	alkaline ceramidase 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty aci [...] (275 aa)		•	•	0.955
	ACER1	alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty aci [...] (264 aa)		•	•	0.955

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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