PARK7 protein (Homo sapiens) - STRING interaction network

PARK7 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	PARK7	Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androgen receptor- dependent transcription. May function as a redox-sensitive chaperone and as a sensor for oxidative stress. Prevents aggregation of SNCA. Protects neurons against oxidative stress and cell death. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity (189 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SNCA	synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)		•	•	•	0.999
	PINK1	PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stre [...] (581 aa)				•	0.993
	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)		•		•	0.986
	ATP13A2	ATPase type 13A2 (1180 aa)				•	0.969
	PTEN	phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatas [...] (403 aa)				•	0.963
	SOD1	superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells [...] (154 aa)	•	•		•	0.957
	SUMO1	SUMO1 pseudogene 3; Ubiquitin-like protein which can be covalently attached to target lysines a [...] (101 aa)		•		•	0.954
	MAPT	microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be i [...] (776 aa)				•	0.953
	AR	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that re [...] (920 aa)		•		•	0.949
	PIAS2	protein inhibitor of activated STAT, 2; Functions as an E3-type small ubiquitin-like modifier ( [...] (621 aa)		•		•	0.946

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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