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  RTN4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
RTN4
reticulon 4; Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing (1192 aa)
(Homo sapiens)
Predicted Functional Partners:
RTN4R
reticulon 4 receptor; Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may [...] (473 aa)
     0.999
OMG
oligodendrocyte myelin glycoprotein; Cell adhesion molecule contributing to the interactive pro [...] (440 aa)
      0.999
MAG
myelin associated glycoprotein; Adhesion molecule in postnatal neural development that mediates [...] (626 aa)
       0.991
NGFR
nerve growth factor receptor (TNFR superfamily, member 16); Low affinity receptor which can bin [...] (427 aa)
      0.989
LINGO1
leucine rich repeat and Ig domain containing 1; Functional component of the Nogo receptor signa [...] (620 aa)
      0.977
UQCRC2
ubiquinol-cytochrome c reductase core protein II; This is a component of the ubiquinol-cytochro [...] (453 aa)
     0.959
BACE1
beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid prec [...] (501 aa)
       0.953
UQCRC1
ubiquinol-cytochrome c reductase core protein I; This is a component of the ubiquinol-cytochrom [...] (480 aa)
      0.952
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho [...] (204 aa)
      0.942
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myoky [...] (495 aa)
      0.938
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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