RTN4 protein (Homo sapiens) - STRING interaction network

RTN4 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	RTN4	reticulon 4; Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing (1192 aa)
		(Homo sapiens)
Predicted Functional Partners:
	RTN4R	reticulon 4 receptor; Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may [...] (473 aa)		•	•	•	0.999
	OMG	oligodendrocyte myelin glycoprotein; Cell adhesion molecule contributing to the interactive pro [...] (440 aa)			•	•	0.999
	MAG	myelin associated glycoprotein; Adhesion molecule in postnatal neural development that mediates [...] (626 aa)				•	0.991
	NGFR	nerve growth factor receptor (TNFR superfamily, member 16); Low affinity receptor which can bin [...] (427 aa)			•	•	0.989
	LINGO1	leucine rich repeat and Ig domain containing 1; Functional component of the Nogo receptor signa [...] (620 aa)			•	•	0.977
	UQCRC2	ubiquinol-cytochrome c reductase core protein II; This is a component of the ubiquinol-cytochro [...] (453 aa)	•	•		•	0.959
	BACE1	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid prec [...] (501 aa)				•	0.953
	UQCRC1	ubiquinol-cytochrome c reductase core protein I; This is a component of the ubiquinol-cytochrom [...] (480 aa)		•		•	0.952
	ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho [...] (204 aa)			•	•	0.942
	KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myoky [...] (495 aa)		•		•	0.938

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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