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  LCK protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
LCK
lymphocyte-specific protein tyrosine kinase; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity [...] (509 aa)
(Homo sapiens)
Predicted Functional Partners:
CD4
CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regul [...] (458 aa)
     0.999
CD247
CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal t [...] (164 aa)
    0.999
PTPRC
protein tyrosine phosphatase, receptor type, C; Required for T-cell activation through the anti [...] (1304 aa)
    0.999
CD8A
CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing t [...] (235 aa)
    0.999
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in [...] (533 aa)
     0.999
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa; Plays a role in T-cell development and lympho [...] (619 aa)
   0.998
CD2
CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 t [...] (351 aa)
     0.998
SYK
spleen tyrosine kinase; Positive effector of BCR-stimulated responses. Couples the B-cell antig [...] (635 aa)
    0.998
IL2
interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this prot [...] (153 aa)
      0.998
PTPN6
protein tyrosine phosphatase, non-receptor type 6; Plays a key role in hematopoiesis. This PTPa [...] (624 aa)
    0.998
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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