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  SMAD3 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SMAD3
SMAD family member 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity) (425 aa)
(Homo sapiens)
Predicted Functional Partners:
ZFYVE9
zinc finger, FYVE domain containing 9; Involved in recruiting unphosphorylated forms of SMAD2/S [...] (1425 aa)
     0.999
SMAD4
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)
    0.999
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in re [...] (785 aa)
     0.999
TGFBR1
transforming growth factor, beta receptor 1; On ligand binding, forms a receptor complex consis [...] (503 aa)
     0.998
SMURF2
SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase which accepts ubiquiti [...] (748 aa)
      0.998
SKI
v-ski sarcoma viral oncogene homolog (avian); May play a role in terminal differentiation of sk [...] (728 aa)
      0.997
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
      0.996
TGFBR2
transforming growth factor, beta receptor II (70/80kDa); On ligand binding, forms a receptor co [...] (592 aa)
     0.995
SKIL
SKI-like oncogene; May have regulatory role in cell division or differentiation in response to [...] (684 aa)
      0.994
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
     0.993
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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