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  BCL2 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
BCL2
B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (239 aa)
(Homo sapiens)
Predicted Functional Partners:
BAD
BCL2-associated agonist of cell death; Promotes cell death. Successfully competes for the bindi [...] (168 aa)
     0.999
BCL2L11
BCL2-like 11 (apoptosis facilitator); Induces apoptosis. Isoform BimL is more potent than isofo [...] (198 aa)
      0.999
BBC3
BCL2 binding component 3; Essential mediator of p53-dependent and p53-independent apoptosis (261 aa)
     0.999
BID
BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release [...] (241 aa)
     0.999
BAX
BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing th [...] (218 aa)
    0.999
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
     0.999
BIK
BCL2-interacting killer (apoptosis-inducing); Accelerates programmed cell death. Binding to the [...] (160 aa)
      0.999
BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that, which can ove [...] (194 aa)
      0.999
FKBP8
FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound [...] (413 aa)
     0.999
NR4A1
nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor (598 aa)
     0.998
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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