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  PSEN1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PSEN1
presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin [...] (467 aa)
(Homo sapiens)
Predicted Functional Partners:
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
     0.999
NCSTN
nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catal [...] (709 aa)
     0.999
PSENEN
presenilin enhancer 2 homolog (C. elegans); Essential subunit of the gamma-secretase complex, a [...] (101 aa)
     0.999
APH1A
anterior pharynx defective 1 homolog A (C. elegans); Essential subunit of the gamma-secretase c [...] (265 aa)
     0.999
NOTCH1
Notch homolog 1, translocation-associated (Drosophila); Functions as a receptor for membrane-bo [...] (2555 aa)
     0.999
APP
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and deg [...] (770 aa)
      0.999
DLL1
delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of [...] (723 aa)
     0.999
APH1B
anterior pharynx defective 1 homolog B (C. elegans); Probable subunit of the gamma-secretase co [...] (257 aa)
     0.997
CDH1
cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion prot [...] (882 aa)
      0.997
KCNIP3
Kv channel interacting protein 3, calsenilin; Calcium-dependent transcriptional repressor that [...] (256 aa)
      0.997
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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