PENK protein (Homo sapiens) - STRING interaction network

PENK protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	PENK	proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum (267 aa)
		(Homo sapiens)
Predicted Functional Partners:
	OPRK1	opioid receptor, kappa 1; Inhibits neurotransmitter release by reducing calcium ion currents an [...] (380 aa)	•	•	0.991
	POMC	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)	•	•	0.990
	OPRM1	opioid receptor, mu 1; Inhibits neurotransmitter release by reducing calcium ion currents and i [...] (493 aa)	•	•	0.984
	OPRD1	opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents an [...] (372 aa)	•	•	0.983
	NPY	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-r [...] (97 aa)	•	•	0.981
	DRD2	dopamine receptor D2; This is one of the five types (D1 to D5) of receptors for dopamine. The a [...] (443 aa)	•	•	0.976
	SST	somatostatin; Somatostatin inhibits the release of somatotropin (116 aa)	•	•	0.976
	OPRL1	opiate receptor-like 1; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential r [...] (370 aa)	•	•	0.964
	JUN	jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)		•	0.964
	FOS	FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but [...] (380 aa)		•	0.962

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: medium (58%)

Permalink