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  LEP protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
LEP
leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass (167 aa)
(Homo sapiens)
Predicted Functional Partners:
LEPR
leptin receptor; Receptor for obesity factor (leptin). On ligand binding, mediates signaling th [...] (1165 aa)
     0.999
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor); Transcription [...] (770 aa)
     0.999
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
      0.998
PTPN1
protein tyrosine phosphatase, non-receptor type 1; May play an important role in CKII- and p60c [...] (435 aa)
      0.997
SOCS3
suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)
      0.996
GHRL
ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor [...] (117 aa)
      0.995
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
       0.994
POMC
proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
       0.994
ADIPOQ
adiponectin, C1Q and collagen domain containing; Important adipokine involved in the control of [...] (244 aa)
      0.994
INSR
insulin receptor; This receptor binds insulin and has a tyrosine-protein kinase activity. Isofo [...] (1382 aa)
       0.993
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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