ADAM17 protein (Homo sapiens) - STRING interaction network

ADAM17 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	ADAM17	ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity) (824 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TIMP3	TIMP metallopeptidase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and [...] (211 aa)	•		•		0.994
	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/T [...] (461 aa)		•	•		0.984
	EGF	epidermal growth factor (beta-urogastrone); EGF stimulates the growth of various epidermal and [...] (1207 aa)		•	•		0.980
	EGFR	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)			•		0.973
	TGFA	transforming growth factor, alpha; TGF alpha is a mitogenic polypeptide that is able to bind to [...] (160 aa)	•		•		0.966
	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that [...] (205 aa)	•		•		0.957
	NOTCH1	Notch homolog 1, translocation-associated (Drosophila); Functions as a receptor for membrane-bo [...] (2555 aa)	•	•	•	•	0.956
	CX3CL1	chemokine (C-X3-C motif) ligand 1; The soluble form is chemotactic for T-cells and monocytes, b [...] (397 aa)			•		0.948
	HBEGF	heparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular prolife [...] (208 aa)		•	•		0.945
	FHL2	four and a half LIM domains 2; May function as a molecular transmitter linking various signalin [...] (279 aa)	•		•		0.945

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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