ADAM17 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity) (824 aa)
(Homo sapiens)
Predicted Functional Partners:
TIMP metallopeptidase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and [...] (211 aa)
tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/T [...] (461 aa)
epidermal growth factor (beta-urogastrone); EGF stimulates the growth of various epidermal and [...] (1207 aa)
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
transforming growth factor, alpha; TGF alpha is a mitogenic polypeptide that is able to bind to [...] (160 aa)
MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that [...] (205 aa)
Notch homolog 1, translocation-associated (Drosophila); Functions as a receptor for membrane-bo [...] (2555 aa)
chemokine (C-X3-C motif) ligand 1; The soluble form is chemotactic for T-cells and monocytes, b [...] (397 aa)
heparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular prolife [...] (208 aa)
four and a half LIM domains 2; May function as a molecular transmitter linking various signalin [...] (279 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (1%)