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  PLG protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PLG
plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4 (810 aa)
(Homo sapiens)
Predicted Functional Partners:
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), m [...] (491 aa)
     0.999
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; [...] (402 aa)
     0.999
FN1
fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)
     0.998
PLAUR
plasminogen activator, urokinase receptor; Acts as a receptor for urokinase plasminogen activat [...] (335 aa)
      0.997
SPARC
secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through [...] (303 aa)
     0.996
HRG
histidine-rich glycoprotein; The physiological function is not yet known. It binds heme, dyes a [...] (525 aa)
     0.994
KNG1
kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an impor [...] (644 aa)
    0.992
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1; Most important serine protease in [...] (464 aa)
      0.992
F5
coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves [...] (2224 aa)
      0.990
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Activation of the C1 complex is u [...] (500 aa)
     0.986
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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