PLG protein (Homo sapiens) - STRING interaction network

PLG protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	PLG	plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4 (810 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), m [...] (491 aa)		•	•	•	0.999
	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; [...] (402 aa)		•	•	•	0.999
	FN1	fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)		•	•	•	0.998
	PLAUR	plasminogen activator, urokinase receptor; Acts as a receptor for urokinase plasminogen activat [...] (335 aa)			•	•	0.997
	SPARC	secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through [...] (303 aa)		•	•	•	0.996
	HRG	histidine-rich glycoprotein; The physiological function is not yet known. It binds heme, dyes a [...] (525 aa)	•	•		•	0.994
	KNG1	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an impor [...] (644 aa)	•	•	•	•	0.992
	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1; Most important serine protease in [...] (464 aa)		•		•	0.992
	F5	coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves [...] (2224 aa)			•	•	0.990
	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Activation of the C1 complex is u [...] (500 aa)		•	•	•	0.986

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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