CYLD protein (Homo sapiens) - STRING interaction network

CYLD protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	CYLD	cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF- kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6 (956 aa)
		(Homo sapiens)
Predicted Functional Partners:
	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)	•	•	•	0.999
	TRAF2	TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)	•		•	0.997
	BCL3	B-cell CLL/lymphoma 3; Could be a transcriptional activating factor. Functions as a form of I-k [...] (454 aa)	•		•	0.991
	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)		•	•	0.990
	TRAF6	TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)	•		•	0.988
	RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF si [...] (671 aa)	•	•	•	0.986
	TRADD	TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically ass [...] (312 aa)		•	•	0.943
	GP1BA	glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, [...] (640 aa)			•	0.938
	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Involved in innate immune defense against viruses. U [...] (925 aa)	•	•	•	0.925
	STAT1	signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of t [...] (750 aa)		•	•	0.916

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: medium (68%)

Permalink