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  CYLD protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CYLD
cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF- kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6 (956 aa)
(Homo sapiens)
Predicted Functional Partners:
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)
     0.999
TRAF2
TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)
      0.997
BCL3
B-cell CLL/lymphoma 3; Could be a transcriptional activating factor. Functions as a form of I-k [...] (454 aa)
      0.991
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
      0.990
TRAF6
TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)
      0.988
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF si [...] (671 aa)
     0.986
TRADD
TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically ass [...] (312 aa)
      0.943
GP1BA
glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, [...] (640 aa)
       0.938
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Involved in innate immune defense against viruses. U [...] (925 aa)
     0.925
STAT1
signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of t [...] (750 aa)
      0.916
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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