PRSS1 protein (Homo sapiens) - STRING interaction network

PRSS1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PRSS1	protease, serine, 2 (trypsin 2); Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates (247 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SPINK1	serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological functi [...] (79 aa)			•	0.993
	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Inhibitor [...] (418 aa)	•		•	0.944
	F2RL1	coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes [...] (397 aa)		•	•	0.918
	PGC	progastricsin (pepsinogen C); Hydrolyzes a variety of proteins (388 aa)			•	0.917
	F2R	coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin couple [...] (425 aa)		•	•	0.912
	MBL2	mannose-binding lectin (protein C) 2, soluble (opsonic defect); Calcium-dependent lectin involv [...] (248 aa)			•	0.880
	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), m [...] (491 aa)	•		•	0.871
	A2M	alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping [...] (1474 aa)			•	0.838
	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member [...] (1480 aa)			•	0.833
	SLPI	secretory leukocyte peptidase inhibitor; Acid-stable proteinase inhibitor with strong affinitie [...] (132 aa)	•		•	0.829

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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