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  CTLA4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CTLA4
cytotoxic T-lymphocyte-associated protein 4; Possibly involved in T-cell activation. Binds to B7-1 (CD80) and B7-2 (CD86) (223 aa)
(Homo sapiens)
Predicted Functional Partners:
CD80
CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-c [...] (288 aa)
     0.999
CD86
CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte prolife [...] (329 aa)
     0.999
FOXP3
forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune [...] (431 aa)
      0.994
AP2M1
adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP [...] (435 aa)
      0.992
LCK
lymphocyte-specific protein tyrosine kinase; Tyrosine kinase that plays an essential role for t [...] (509 aa)
     0.990
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
     0.985
ICOS
inducible T-cell co-stimulator; Enhances all basic T-cell responses to a foreign antigen, namel [...] (199 aa)
      0.985
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; Plays a role in the [...] (925 aa)
      0.984
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)
     0.972
IL2
interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this prot [...] (153 aa)
       0.970
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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