LRRK2 protein (Homo sapiens) - STRING interaction network

LRRK2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	LRRK2	leucine-rich repeat kinase 2; Probable protein kinase whose role is not yet known. May play a role in the phosphorylation of proteins central to Parkinson disease. May also have GTPase activity (2527 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SNCA	synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)	•	•	0.995
	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)	•	•	0.973
	ATP13A2	ATPase type 13A2 (1180 aa)		•	0.957
	PARK7	Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androge [...] (189 aa)		•	0.930
	MAPT	microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be i [...] (776 aa)		•	0.920
	MSN	moesin; Probably involved in connections of major cytoskeletal structures to the plasma membran [...] (577 aa)		•	0.913
	GBA	glucosidase, beta; acid (includes glucosylceramidase) (536 aa)		•	0.903
	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase [...] (223 aa)		•	0.901
	EIF2C1	eukaryotic translation initiation factor 2C, 1; Required for RNA-mediated gene silencing (RNAi) [...] (857 aa)		•	0.892
	SCPEP1	serine carboxypeptidase 1; May be involved in vascular wall and kidney homeostasis (By similari [...] (452 aa)		•	0.887

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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