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  PHOX2A protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PHOX2A
paired-like homeobox 2a; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (284 aa)
(Homo sapiens)
Predicted Functional Partners:
ASCL1
achaete-scute complex homolog 1 (Drosophila); May play a role at early stages of development of [...] (236 aa)
       0.975
KIF21A
kinesin family member 21A; Microtubule-binding motor protein probably involved in neuronal axon [...] (1661 aa)
       0.953
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
       0.949
HAND2
heart and neural crest derivatives expressed 2; Essential for cardiac morphogenesis, particular [...] (217 aa)
      0.908
CREB1
cAMP responsive element binding protein 1; This protein binds the cAMP response element (CRE), [...] (341 aa)
       0.893
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenalin [...] (617 aa)
       0.883
RET
ret proto-oncogene; Probable receptor with tyrosine-protein kinase activity; important for deve [...] (1114 aa)
       0.882
TH
tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons (528 aa)
       0.863
GDNF
glial cell derived neurotrophic factor; Neurotrophic factor that enhances survival and morpholo [...] (211 aa)
       0.848
INPPL1
inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that speci [...] (1258 aa)
       0.772
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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